Siskiyou County is a county located in far northernmost California, USA, in the Cascade Mountains on the Oregon border. As of 2000 the population was 44,301. The county seat is Yreka. According to the U.S. Census Bureau, the county has a total area of 16,440 km² (6,347 mi²). 16,283 km² (6,287 mi²) of it is land and 157 km² (61 mi²) of it is water. The total area is 0.96% water. As of the census2 of 2000, there were 44,301 people, 18,556 households, and 12,228 families residing in the county. The population density was 3/km² (7/mi²). There were 21,947 housing units at an average density of 1/km² (4/mi²). The racial makeup of the county was 87.07% White, 1.31% Black or African American, 3.90% Native American, 1.19% Asian, 0.13% Pacific Islander, 2.76% from other races, and 3.65% from two or more races. 7.57% of the population were Hispanic or Latino of any race.